Optimization And Stability Testing Of Avocado Leaf (*Persea americana*) Extract Soap Formulated With A Combination Of VCO, Palm Oil, And Olive Oil Using The Simplex Lattice Design Method

Sandhi Nugraheni; Anna Fitriawati; Bagas Ardiyantoro

doi:10.55227/ijhet.v5i3.1192

Authors

Sandhi Nugraheni Program Studi Sarjana Farmasi, Fakultas Ilmu Kesehatan, Universitas Duta Bangsa Surakarta
Anna Fitriawati Program Studi Sarjana Farmasi, Fakultas Ilmu Kesehatan, Universitas Duta Bangsa Surakarta
Bagas Ardiyantoro Program Studi Sarjana Farmasi, Fakultas Ilmu Kesehatan, Universitas Duta Bangsa Surakarta

DOI:

https://doi.org/10.55227/ijhet.v5i3.1192

Keywords:

Antioxidant, Solid Soap,SLD, Avocado

Abstract

Continuous exposure to free radicals such as sunlight, air pollution, and cigarette smoke can cause dry, dull skin, skin lesions, and premature aging. Therefore, it is necessary to utilize natural ingredients with antioxidant properties to address these issues. Avocado (Persea americana) leaves are known to contain various secondary metabolites such as flavonoids, saponins, alkaloids, and tannins, which have high antioxidant activity. The use of these natural ingredients in solid soap offers a safe and effective solution to protect the skin from the negative effects of free radicals. This study was conducted to determine the optimum formula and combination of VCO, palm oil, and olive oil in the manufacture of avocado leaf extract soap. Stability and antioxidant tests were conducted. Optimization using the Simplex Lattice Design (SLD) method aims to determine the precise concentrations of ingredients to obtain a formula with optimal physical properties and a consumer-acceptable response. This study was optimized using the Simplex lattice design method, antioxidant testing using the DPPH method, and stability testing using a cycling test. The results showed that avocado leaf extract has very strong antioxidant activity, with an IC₅₀ value of 16.127 μg/mL. Formula optimization using Simplex lattice design resulted in an optimal formula with 10% VCO, 30% palm oil, and 10% olive oil. Solid soap was formulated with avocado leaf extract into three formulas. Formula 3, with a 10% extract concentration, achieved the highest IC₅₀ value of 17.878 μg/mL. Thus, avocado leaf extract has very strong antioxidant content.

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